Indomethacin therapy can be provided for asymptomatic women with a short cervix (less than 25 mm) at 14 to 27 weeks and who did not receive a cerclage. This can be used to prolong pregnancy by slowing preterm uterine contractions. Indomethacin can be given orally, through injection, or in the rectum. Indomethacin works by blocking prostaglandins, which is a substance that contributes to uterine contractions.
Procardia (known as Nifedipine) is sometimes used during preterm labor to slow contractions. Nifedipine is used as a calcium blocker, which is commonly used to treat high blood pressure. The treatment works by blocking the calcium passages that help the uterus contract, therefore relaxing uterine tissues and slowing preterm labor. Nifedipine can be used to treat preterm labor when regular contractions have thinned, the cervix is less than 4 cm dilated, labor needs to be delayed 24 to 48 hours, and treatment of other tocolytics medicines were stopped due to side effects.